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What is NAD+ and NMN, and how are they relevant to aging?

NAD+ Biosynthetic Pathway
HighTech approach to living Longer

NAD+ is a crucial molecule with a wide range of effects in our cells. It plays a vital role in enabling the proper functioning of sirtuins, which are enzymes responsible for protecting our DNA and regulating the epigenome. The epigenome, in turn, is the intricate machinery surrounding DNA that determines which genes are active and influences protein production in cells. It's a very complex system that ensures only relevant genes are active in specific cell types, such as gut genes in gut cells and not in skin or brain cells, despite all cells having the same DNA.

As we age, NAD+ production becomes increasingly dysregulated. This decline in NAD+ levels is associated with various negative outcomes, including a decrease in metabolism leading to weight gain and an increased risk of type 2 diabetes, metabolic syndrome, fatty liver, and other metabolic disorders. Additionally, it's linked to reduced blood vessel health, age-related muscle loss, cognitive decline, eyesight and hearing deterioration, and a shorter lifespan.

Increasing NAD+ levels is associated with improved metabolic health, increased energy, muscle maintenance, enhanced cognition, cardiovascular health, and more.

So, how can we increase NAD+ levels?

Taking NAD+ orally is not recommended because most NAD+ is broken down in the stomach and gut, and the molecules are too large to be absorbed into the bloodstream. Some people turn to intravenous NAD+ injections, but this approach results in a rapid spike of NAD+ levels that quickly diminishes. Moreover, NAD+ infusions are typically administered irregularly, not on a continuous, daily basis.

Instead of NAD+, you can take NMN, which is a direct precursor to NAD+ and the most effective way to increase NAD+ levels. NMN is absorbed in the gut and remains stable in the bloodstream, allowing for a continuous increase in NAD+ levels.

Nicotinamide Mononucleotide (NMN) supplements are often considered one of the most promising interventions to slow down the aging process. NMN impacts aging through:

  • Mitochondrial dysfunction

  • Stem cell exhaustion

  • Epigenetic alterations

  • Altered intercellular communication

  • Deregulated nutrient sensing

  • Disabled macroautophagy

  • Genomic instability

NMN is a natural substance found in fruits, milk, and vegetables. In our bodies, NMN provides the necessary "fuel" for crucial enzymes to maintain the epigenome, repair DNA, and carry out other essential functions.

NMN can be taken orally and is well-absorbed. It's one of the most well-studied natural substances for slowing down aging. Recent studies suggest that NMN is likely the most effective NAD+ booster for anti-aging purposes, which is why acclaimed aging specialists like Harvard Professor David Sinclair choose NMN.

However, given NMN’s high price, many online NMN sellers offer adulterated or low-quality NMN. To save you time and money, I recommend NOVOS supplements, which contain high-quality, high-purity, stable NMN at a great price. NOVOS is the only company targeting the 12 causes of aging using multiple ingredients, an approach backed by top scientists.

🩵 You can get 6-month and 12-month subscriptions (15% and 27% off, respectively) by using this link:, and get an additional $5 off with the promo code SMILA.

🌹 Join the 3-day Ultimate Wellness Retreat at the FAENA Hotel on November 17-19, 2023, to learn about both Low-Tech and High-Tech strategies for reversing biological age. Our retreat is designed for your Complete Reset Across All Levels: Spiritual, Psychological, Emotional, and Physical. For more information, please visit or reach out to me.

Sending You Optimal Health & Ultimate Wellness,

Julia Smila - Consciousness Entrepreneur, Biohacker, FDN-Practitioner & Pranic Healer

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